SecReT6, T6SS database

Regulators of regulatory pathway: Cysteine and methionine metabolism

All displayed regulators are experimentally validated.

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0224	ETAE_2773 (mtnN)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2910743..2911441 (+)	502612632	ETAE_0886 (esrB) promoter (↑)
REG0298	VCA1552_RS01665 (LuxS)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	319588..320106 (+)	447052971	Hcp expression and secretion (↓)
REG0066	PA3476 (rhlI)	T6SS00004	protein	QS regulatory pathway	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	3889139..3889744 (-)	15598672	PA3477 (RhlR) (↓)
REG0327	WQ49_05060 (cepI)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000002)	547435..548043 (+)	815852485	T6SS expression (↓)
REG0093	ECA_RS00520 (expI)	T6SS00040	protein	QS regulatory pathway	Pectobacterium atrosepticum SCRI1043	chromosome (NC_004547)	125689..126339 (+)	499404281	T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0197	YPK_RS08350 (ypsI)	T6SS00256	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1838406..1839050 (-)	501053391	T6SS transcripts (↓)
REG0198	YPK_RS03970 (ytbI)	T6SS00256 ; T6SS00260	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	901200..901850 (-)	488144695	T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0322	GT391_RS06405 (expI)	T6SS01170	protein	QS regulatory pathway	Pectobacterium brasiliense strain 1692	chromosome (NZ_CP047495)	1436931..1437581 (-)	497970044	GT391_RS06470 (expR1) (↓)
REG0121	CV_RS23145 (CviI)	T6SS00049	protein	QS regulatory pathway	Chromobacterium violaceum ATCC 12472	chromosome (NC_005085)	4426967..4427620 (-)	499450174	CV_RS20220 (CviR) (↓)
REG0370	ACX60_RS11355 (racK)	T6SS01046	protein	Environmental signal	Acinetobacter baumannii strain ATCC 17978	chromosome (NZ_CP012004)	2382673..2383965 (+)	WP_000769882.1	ACX60_RS00605 (Tse4) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0224	ETAE_2773 (mtnN)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	2910743..2911441 (+)	502612632	ETAE_0886 (esrB) promoter (↑)
REG0298	VCA1552_RS01665 (LuxS)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	319588..320106 (+)	447052971	Hcp expression and secretion (↓)
REG0066	PA3476 (rhlI)	T6SS00004	protein	QS regulatory pathway	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	3889139..3889744 (-)	15598672	PA3477 (RhlR) (↓)
REG0327	WQ49_05060 (cepI)	T6SS01276	protein	QS regulatory pathway	Burkholderia cenocepacia strain K56-2	chromosome (LAUA01000002)	547435..548043 (+)	815852485	T6SS expression (↓)
REG0093	ECA_RS00520 (expI)	T6SS00040	protein	QS regulatory pathway	Pectobacterium atrosepticum SCRI1043	chromosome (NC_004547)	125689..126339 (+)	499404281	T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0197	YPK_RS08350 (ypsI)	T6SS00256	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	1838406..1839050 (-)	501053391	T6SS transcripts (↓)
REG0198	YPK_RS03970 (ytbI)	T6SS00256 ; T6SS00260	protein	QS regulatory pathway	Yersinia pseudotuberculosis YPIII	chromosome (NC_010465)	901200..901850 (-)	488144695	T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0322	GT391_RS06405 (expI)	T6SS01170	protein	QS regulatory pathway	Pectobacterium brasiliense strain 1692	chromosome (NZ_CP047495)	1436931..1437581 (-)	497970044	GT391_RS06470 (expR1) (↓)
REG0121	CV_RS23145 (CviI)	T6SS00049	protein	QS regulatory pathway	Chromobacterium violaceum ATCC 12472	chromosome (NC_005085)	4426967..4427620 (-)	499450174	CV_RS20220 (CviR) (↓)
REG0370	ACX60_RS11355 (racK)	T6SS01046	protein	Environmental signal	Acinetobacter baumannii strain ATCC 17978	chromosome (NZ_CP012004)	2382673..2383965 (+)	WP_000769882.1	ACX60_RS00605 (Tse4) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)